Allogeneic morphogenetic protein vs. recombinant human bone morphogenetic protein-2 in lumbar interbody fusion procedures: a radiographic and economic analysis
نویسندگان
چکیده
منابع مشابه
Allogeneic morphogenetic protein vs. recombinant human bone morphogenetic protein-2 in lumbar interbody fusion procedures: a radiographic and economic analysis
BACKGROUND Since the introduction of rhBMP-2 (Infuse) in 2002, surgeons have had an alternative substitute to autograft and its related donor site morbidity. Recently, the prevalence of reported adverse events and complications related to the use of rhBMP-2 has raised many ethical and legal concerns for surgeons. Additionally, the cost and decreasing reimbursement landscape of rhBMP-2 use have ...
متن کاملSafety of transforaminal lumbar interbody fusion and intervertebral recombinant human bone morphogenetic protein-2.
OBJECT Recombinant human bone morphogenetic protein-2 (rhBMP-2) is being increasingly used for spinal fusion. There are few data regarding its clinical safety, effectiveness, and clinical outcome when applied on an absorbable collagen sponge (ACS) in conjunction with allograft for transforaminal lumbar interbody fusion (TLIF). METHODS Seventy-four consecutive patients undergoing TLIF for dege...
متن کاملOsteolysis in Lumbar Interbody Fusions: The Role of Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2)
Osteolysis may occur following lumbar interbody fusion procedures in which recombinant human bone morphogenetic protein-2, more commonly known as rhBMP-2, is used. The actual incidence of this process is unknown. Osteolysis results from an osteoclastic, rather than an osteoblastic response to rhBMP-2 and its carrier on trabecular vertebral bone, early in the sequence of bone graft healing. This...
متن کاملA Retrospective Analysis of Complications Associated With Bone Morphogenetic Protein 2 in Anterior Lumbar Interbody Fusion
STUDY DESIGN Retrospective review. OBJECTIVE The aim of our study was to quantify the frequency of complications associated with recombinant human bone morphogenetic protein 2 (rhBMP-2) use in anterior lumbar interbody fusion (ALIF). METHODS The orthopedic subset of the Medicare database (PearlDiver) was queried for this retrospective cohort study using International Statistical Classificat...
متن کاملThe effect of recombinant human bone morphogenetic protein-2 in single-level posterior lumbar interbody arthrodesis.
BACKGROUND In this prospective, randomized controlled trial, our objective was to assess both the clinical and radiographic effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) in patients treated with an instrumented single-level posterior lumbar interbody arthrodesis with polyetheretherketone cages. METHODS Forty patients were randomized with a 1:1 ratio. Two patients who had ...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Surgery and Research
سال: 2013
ISSN: 1749-799X
DOI: 10.1186/1749-799x-8-49